As others have indicated, ETTR may help, though the Z8 is functionally iso-invariant so the real factors are overall illumination (photons). Shadow areas can become particularly challenging and loose detail in favor of the noise. In terms of strategies for managing the high ISO images, the strategy I've adopted depends more on the output. If the image is intended for print, I'll favor preservation of color and detail over NR whereas if the output is slated for the web NR tends to prevail.
Usually, up to ISO's of 6400 images are usually easily managed though it tends to become a bit more problematic at 12,800 and beyond. With the higher ISO's it becomes more of a struggle trying to preserve detail and color fidelity and I've adopted a two stage approach to addressing the noise. First, I do some general NR in whatever the RAW processor (DxO, On1 PR, etc.), tweaking the NR for modest gains albeit not sacrificing color and detail. Then after the image has been PP'ed, I send it to Topaz Noise Reduction AI, not the Photo AI which has limited NR models and work on the image from there. Depending on the particular image, one NR model seems to work better than others so I've found NRAI works better than Photo AI.