I haven't tried handoff with AF area cycling…but it seems that if you've got focus persistence turned on it ought to work. Finger of the AF On button, toggle the area, and Finger on AF On and it ought to work. However…I think this would be one of those situations where you only wanted a pair of areas on the cycle button or else the subject might move out of the focus persistence area or distance…and rather than limit cycle to 2 areas I think that using a second button for AF Area and AF On for handoff would be more efficient…assuming you've got a button you're willing to use for that. I'm currently keeping just 4 areas on my cycle button because they're about the only ones I use…and while my setup is a lot like Steve's I also use some of Hudson Henry's ideas…DISP gets a specific area and AF On, AF ON uses the currently selected area and the DISP area is not on the cycle option…and Fn is for DX and Fn2 is RSF Hold with SD Off. If I really need one of the other areas…either the iMenu or AF Area button on the front left gets me there.