It compares favorably to the 100-500 + 1.4x TC, not the native lens. I found the optical quality of the pair (100-500 + tc) unacceptable for cropping or, subjects towards the edges, or those which didn't fill the entire frame. The MTF data looks better than the 800 f/11 so that's positive though let's wait to see some images from production copies.
I don't know, pretty favorable in the center and midrange, even compared to the 100-500 at 100 vs. the 200-800 at 200. Drops way off in the corners, but eventually DXO will have a profile for that. I'd like to see a more in-depth comparison between the 100-500 and the 200-800. The 100=500 is down to $2500 or so it would still be preferable to me if one didn't need the extra reach.