There is another thread on the 400 f/4.5 and whether or not photographers may sell that lens to get the new 180-600 but I think another good question is how valid is the 100-400 S vs. the 180-600? Granted the 100-400 is an "S" lens so one would assume has the better glass and therefore better IQ, but it seems Nikon appears to be using some pixy dust with their non-S lens counterparts and they are showing surprising promise. Given the fact that some of us likely have the 24-120 f/4 S lens and maybe even a 70-200 (or even the new 70-180 f/2.8 is on the radar) the question is whether or not the 100-400 even makes sense with a 24-120 and 180-600 combo, will that gap between 120-180 make that big of a difference? Will the 100-400 S be "that much better" than the 180-600 IQ wise or AF (speed) wise? Granted we don't even have production units out, but I'm really liking the specs of the 180-600 thus far and it's making me think the 100-400 may be the lens that could be dropped more than others. I had the 100-400 when it was first released and I have the 70-200 f/2.8 S with 2x TC as a stop gap until something else piqued my interest as I could not see a big enough difference between 100-400 and the 70-200 with 2x TC, maybe I wasn't critical enough or maybe it was because all I had was the Z6 at the time, now I have the Z8 so maybe I would start seeing a difference with the 100-400? Curious if others agree and/or what you're thinking.