Keep in mind that since the mirrorless cameras are using on-sensor PDAF they can also be affected by noise as well. If the noise overwhelms the detail it can potently cause issues achieving focus since the camera is relaying on finding the a phase differential based on subject detail. If all it sees is noise, it won't focus.
Yes, you are right. Here technical issues arise that go beyond my skills.
What I have described is what happened to me recently with my hiking partner.
He habitually adjusted his Z6 with a limit of 12800 ISO as that is the equivalent value to the adjustment of his D5.
On the other hand, after several tests, I realized that it is better to go up to 32,000, as previously written.
Now I don't want to start a debate on the noise resistance of one model or the other because this is not the place.
But in conclusion, after half a morning of taking pictures of some Deers shortly after dawn, he realized that his ideas were wrong.
I do not know beyond 32,000 iso if digital noise can create problems for the PDAF sensor, but until then, I have not encountered any problems.
Here is an example of a photo of that morning at ISO 25,600, 1/60" F.5.6 at 600mm.
You can only see EXIF info for this image if you are logged in.
Just to give an example of what I am saying.
The photo is slightly lighter than the light it actually was and it, not a crop, the subject was to close to us.