I usually call Denoise AI and Sharpen AI from either LrC or PS. I have Topaz Photo AI, played with it quite a bit and, as of yet, it's not part of my workflow. For me, it tends to over process and I don't seem to have the level of control I get with the individual apps. LrC version 12.3 comes with a new Noise Reduction feature that, IMHO, is actually better than Topaz DeNoise AI. It seems to maintain more of the detail while suppressing noise and there's not as much of a trade off between detail, texture and noise reduction. I haven't found anything as good or better than Sharpen AI though. It works miracles on soft or even blurry images. I wonder how long it will take Adobe to duplicate it?