technically you can. you can buy
u.2 ssd drives up to about 30TB, although obviously they're pretty expensive.
u.2 basically takes the same electronic interface as m.2 nvme drives, and you can even get adapter cables to go from m.2 headers to u.2. alternately, you can put a u.2 (or two u.2, or even four, but it's a long card and you need x16 slot) drives on a pci card and just plug them in. basically it works the same way as a m.2 to pci adapter, basically the interface is just 4x pci lanes.
the pci adapter is probably the easiest way for most of us, but
OWC does have external cases that can take u.2 drives via Thunderbolt
my u.2 boot drive on
an inexpensive pci adapter card: